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Professor Zhang Xiujuan.jpg

Professor Xiujuan Zhang
張秀娟教授

Clinical Assistant Professor
臨床助理教授

Honorary Clinician (Ophthalmology), Queen Mary Hospital
瑪麗醫院名譽臨床醫生
Honorary Clinician (Ophthalmology), Grantham Hospital
葛量洪醫院名譽臨床醫生

PhD (CUHK), MMed(TMU), BMed(TMU)

Phone 電話

(852) 2518 1430

Email 電郵

hxjzhang@hku.hk

About Professor Zhang 關於張教授

Professor Zhang Xiujuan is a clinician-scientist with expertise in research on myopia research, ocular epidemiology, and blindness prevention. She has the research focus on myopia and its intervention, particularly low-concentration atropine eye drops for myopia control. She graduated from the Chinese University of Hong Kong, with a PhD degree in Ophthalmology and Visual Sciences. She has led five ocular epidemiological studies, involving a total of 10,000 subjects, for her PhD projects. She coordinated the Hong Kong Children Eye Study, a comprehensive investigation involving 40,000 children to investigate the epidemiology of myopia and paediatric ocular diseases. Her primary involvement in clinical trials of low-concentration atropine has been instrumental in advancing the treatment and prevention of myopia.
張秀娟教授是一位臨床醫生兼科學家，專注於近視、眼科流行病學和防盲研究。她的研究重點為近視及其干預措施，尤其是用於控制近視的低濃度阿托品眼藥水。她於香港中文大學修畢眼科及視覺科學博士學位，博士期間她帶領了五項眼科流行病學研究項目，涉及共計10,000名參加者。她曾協調組織香港兒童眼科研究，是一項涵蓋了40,000名兒童的全面檢查，以研究近視和兒童眼科疾病的流行病學研究。她在低濃度阿托品臨床試驗中的主要參與對推進近視治療和預防起到了重要作用。

Research and Awards 研究及獎項

As a Principal Investigator, Professor Zhang has obtained seven grants, including four external competitive grants, with funding of HK$7,680,000 from 2020 to 2024. She has more than 60 publications and published in international journals, including JAMA, The Lancet Global Health, JAMA Network Open, Ophthalmology, NPJ Digital Medicine, and JAMA Ophthalmology. She is the recipient of local and international awards and honours in research and professional services including the Global Fellowship Award from the University of St Andrews in the United Kingdom in 2023, the Outstanding Research Impact Award from the Chinese University of Hong Kong in 2022 (Co-I) and Hong Kong Outstanding Youth Volunteer Group Award. The intelligent glasses ‶My-O-Analyser″ as an objective measure for lifestyle monitoring, co-invented by Professor Zhang, has obtained 4 international awards, including a Silver Medal in the Geneva International Exhibition of Inventions. 

張教授在2020年至2024年間以首席研究員獲得七項資助，其中包括四項來自校外資助，總金額為7,680,000港元。她在《美國醫學會雜誌》、《柳葉刀全球健康》、《JAMA Network Open》、《眼科學》、《NPJ數字醫學》和《美國醫學會雜誌眼科學卷》等國際期刊發表了60多篇論文。她在研究和專業服務方面獲得本地和國際獎項和榮譽，包括英國聖安德魯斯大學的全球科研者獎（2023年），香港中文大學的傑出研究影響獎（共同研究員）（2022年），以及香港傑出青年義工團隊獎。由張教授共同研發的——用於監測生活方式的智能眼鏡「My-O-Analyser」——已獲得四項國際獎項，包括日內瓦國際發明展的銀獎。

Research Interests 研究興趣

  1. Myopia and high myopia: epidemiology, genomic investigations, and imaging studies for myopia, and artificial intelligence for myopia and high myopia 

  2. Interventions for myopia: new strategies for controlling myopia progressions and prevention of myopia onset 

  3. Ophthalmic epidemiology: risk factors, prevalence and incidence of major ocular diseases 

  4. Blindness prevention: territory-based epidemiology studies for blindness and visual impairment, including prevalence and risk factors of visual impairment and blindness, barriers for prevention of blindness 

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  1. 近視和高度近視：近視的流行病學、基因研究和影像學研究，以及人工智能在近視與高度近視的研究 

  2. 近視干預：控制近視進展和預防近視發生的新策略

  3. 眼科流行病學：主要眼部疾病的危險因素、患病率和發病率

  4. 防盲研究：基於地區的盲與視力損傷的流行病學研究，包括視力損傷和盲的危險因素，以及預防失明的障礙研究
     

Services and Teaching 服務與教學

Professor Zhang is a member of Asia-Pacific Academy Ophthalmology (APAO) Public Education Committee and International Paediatric Ophthalmology and Strabismus Council (IPOSC) Myopia Committee.  She was invited to join the Scientific Programme Committee and was the Secretary of the Paediatric Ophthalmology and Strabismus programme at the 36th Asia-Pacific Academy of Ophthalmology (APAO) Congress. She is the Secretary of Myopia Programme at the 39th and the 40th Asia-Pacific Academy of Ophthalmology (APAO) Congress. She also serves as a reviewer for international journals. She has supervised and co-supervised 9 PhD students and 8 undergraduate students (including 2 students from Global Physician-Leadership Stream at the Chinese University of Hong Kong) and mentored 6 post-doctoral fellows in their research. She co-authored with these students and published more than 30 papers together. 
張教授是亞太眼科學會公共教育委員會和國際兒童眼科學會及斜視近視委員會的成員。她擔任第36屆亞太眼科學會大會兒童眼科學和斜視項目組秘書， 以及第39屆和第40屆亞太眼科學會大會的近視項目組秘書。她還擔任多個國際期刊的審稿人。她指導和共同指導了9名博士研究生和8名本科生（包括2名香港中文大學環球醫學領袖培訓專修組別的學生），並指導了6名博士後研究員的研究工作。與這些學生合著並發表了30多篇論文。

Selected Publications 精選刊物

  1. Yam JC, Zhang XJ, Zhang Y, Yip BHK, Tang FY, Wong E, Bui CHT, Kam KW, Ng MPH, Ko S, Yip W, Young AL, Tham CC, Chen LJ, Pang CP. Effect of Low-concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children: The LAMP 2 Randomized Clinical Trial. JAMA. 2023; 329 (6): 472-481. doi:  10.1001/jama.2022.24162.

  2. Zhang XJ, Zhang Y, Yam JC. Low-Concentration Atropine Eyedrops for Myopia in Children-Reply. JAMA. 2023;329(21):1886. doi: 10.1001/jama.2023.7289.

  3. Zhang XJ, Zhang Y, Yip BHK, Tang FY, Wong E, Bui CHT, Kam KW, Ng MPH, Ko S, Yip W, Young AL, Tham CC, Chen LJ, Pang CP, Yam JC. Hyperopic Reserve as an Indicator of Myopia Prevention by Atropine (LAMP2 Study). Ophthalmology. Published online June 11, 2024. doi: 10.1016/j.ophtha.2024.06.010.

  4. Zhang XJ, Zhang Y, Yip BHK, Tang FY, Wong E, Bui CHT, Kam KW, Ng MPH, Ko S, Yip W, Young AL, Tham CC, Chen LJ, Pang CP, Yam JC. Five-Year Clinical Trial of Low-concentration Atropine for Myopia Progression (LAMP) Study: Phase 4 Report. Ophthalmology. Published online March 16, 2024. doi: 10.1016/j.ophtha.2024.03.013.

  5. Zhang XJ, Zhang Y, Kam KW, Tang F, Li Y, Ng MPH, Young AL, Ip P, Tham CC, Chen LJ, Pang CP, Yam JC. Prevalence of Myopia in Children Before, During, and After COVID-19 Restrictions in Hong Kong. JAMA Netw Open. 2023;6(3):e234080.

  6. Zhang XJ, Zaabaar E, French AN, Tang FY, Kam KW, Tham CC, Chen LJ, Pang CP, Yam JC. Advances in myopia control strategies for children. Br J Ophthalmol. Published online May 22, 2024. doi: 10.1136/bjo-2023-323887.

  7. Zhang Y*, Zhang XJ*, Yuan N, Zhang Y, Wang YM, Tang F, Ng MP, Ip P, Kam KW, Young A.L, Chen LJ, Tham CC. Pang CP.  Yam JC. Analysis of Secondhand Smoke Exposure and Myopia in Children Aged 6-8 Years in Hong Kong. JAMA Netw Open. 2023; 6(5):e2313006 . doi: 10.1001/jamanetworkopen.2023.13006. (*co-first author)

  8. Agyekum S, Chan PP, Zhang Y, Huo Z, Yip BHK, Ip P, Tham CC, Chen LJ, Zhang XJ*, Pang CP, Yam JC. Cost-effectiveness Analysis of Myopia Progression Interventions in Children. JAMA Netw Open.  2023;6(11) :e2340986. doi: 10.1001/jamanetworkopen.2023.40986. (*co-senior author)

  9. Cheung CY*, Zhang XJ*, Chan HN, Zhang Y, Yuen VL, Hsu W, Lee ML, Xu D, Wong J, Tang FY, Kam KW, Young A, Ng MP, Ip P, Chen LJ, Wong TY, Pang CP, Tham CC, Yam JC. Influence of Secondhand Smoke Exposure on the Retinal Vasculature of Children: The Hong Kong Children Eye Study. Communications Medicine. 2023;3(1):155. Published online 2023 Oct 26. doi: 10.1038/s43856-023-00389-4. (*co-first author)

  10. Zhang XJ, Chen XN, Tang FY, Szeto S, Ling XT, Lin ZX, Tham CC, Pang CP, Chen LJ, Yam JC. Pathogenesis of myopic choroidal neovascularization: A systematic review and meta-analysis. Surv Ophthalmol. 2023;68(6):1011-1026. doi: 10.1016/j.survophthal.2023.07.006.

  11. Zhang XJ, Tang SM, Wang YM, Zhang Y, Chan HN, Lau YH, Kam KW, Chan PP, Ip P, Young AL, Tham CC, Chen LJ, Pang CP, Yam JC. Increase in Bruch's membrane opening minimum rim width with age in healthy children: the Hong Kong Children Eye Study. Br J Ophthalmol. 2023;107(9), 1344-1349. doi: 10.1136/bjophthalmol-2021-320524.

  12. Zhang XJ, Chau DKS, Wang YM, Chen LJ, Tham CC, Ohno-Matsui K, Young AL, Tham CC, Pang CP, Chen LJ, Yam JC. Prevalence and Characteristics of Peripapillary Gamma Zone in Children With Different Refractive Status: The Hong Kong Children Eye Study. Invest Ophthalmol Vis Sci.  2023;64(4):4. doi: 10.1167/iovs.64.4.4.

  13. Foo LL, Lim GYS, Lanca C, Wong CW, Hoang QV, Zhang XJ, Yam JC, Schmetterer L, Chia A, Wong TY, Ting DSW, Saw SM, Ang M. Deep learning system to predict the 5-year risk of high myopia using fundus imaging in children. NPJ Digit Med. 2023;6(1):10. doi: 10.1038/s41746-023-00752-8.

  14. Zhang X, Cheung SSL, Chan HN, Zhang Y, Wang YM, Yip BH, Kam KW, Yu M, Cheng CY, Young AL, Kwan MYW, Ip P, Chong KK, Tham CC, Chen LJ, Pang CP, Yam JCS. Myopia Incidence and Lifestyle Changes Among School Children During the COVID-19 Pandemic: A Population-based Prospective Study.  Br J Ophthalmol.  2022;106(12):1772-1778. doi: 10.1136/bjophthalmol-2021-319307.

  15. Bourne RRA, Cicinelli MV, Sedighi T, Tapply IH, McCormick I, Jonas JB, Congdon NG, Ramke J, Naidoo KS, Fricke TR, Burton MJ, Müller A, Bikbov MM, Furtado JM, Kyari F, He M, Wang YX, Vijaya L, Nangia V, Brian G, Emamian MH, Fotouhi A, Hashemi H, Khandekar RB, Marmamula S, Salomão S, George R, Kazakbaeva G, Braithwaite T, Casson RJ, Iwase A, Gupta N, Abdianwall MH, Varma R, Wong TY, Wang N, Taylor HR, Flaxman SR, Keel S, Resnikoff S; Vision Loss Expert Group of the Global Burden of Disease Study; Zhang XJ*. (RAAB International Co-Author Group). Effective refractive error coverage in adults aged 50 years and older: estimates from population-based surveys in 61 countries. Lancet Glob Health. 2022;10(12):e1754-e1763. doi: 10.1016/S2214-109X(22)00433-8. (Last author)

  16. McCormick I, Butcher R, Evans JR, Mactaggart IZ, Limburg H, Jolley E, Sapkota YD, Oye JE, Mishra SK, Bastawrous A, Furtado JM, Joshi A, Xiao B, Ravilla TD, Bourne RRA, Cieza A, Keel S, Burton MJ, Ramke J; Zhang XJ*. (RAAB International Co-Author Group). Effective cataract surgical coverage in adults aged 50 years and older: estimates from population-based surveys in 55 countries. Lancet Glob Health. 2022;10(12):e1744-e1753. doi: 10.1016/S2214-109X(22)00419-3. (Last author)

  17. Yam JC, Zhang XJ, Zhang Y, Wang YM, Tang SM, Li FF, Kam KW, Ko ST, Yip BHK, Young AL, Tham CC, Chen LJ, Pang CP. Three-Year Clinical Trial of Low-concentration Atropine for Myopia Progression (LAMP) Study: Continued Versus Washout Phase 3 Report. Ophthalmology. 2022;129(3):308-321. doi: 10.1016/j.ophtha.2021.10.002.

  18. Yam JC, Li FF, Zhang X, Tang SM, Yip BHK, Kam KW, Ko ST, Young AL, Tham CC, Chen LJ, Pang CP. Two-Year Clinical Trial of the Low-concentration Atropine for Myopia Progression (LAMP) Study: Phase 2 report. Ophthalmology. 2020;127(7):910-919. doi: 10.1016/j.ophtha.2019.12.011.

  19. Zhang XJ, Leung CKS, Li EY, Musch DC, Zheng CR, He MG, Chang DF, Lam DSC. Diagnostic Accuracy of Rapid Assessment of Avoidable Blindness: A Population-based Assessment. Am J Ophthalmol. 2020;213:235-243. doi: 10.1016/j.ajo.2019.12.009.

  20. Zhang XJ, Liang YB, Liu YP, Jhanji V, Musch DC, Peng Y, Zheng CR, Zhang HX, Chen P, Tang X, Lam DS. Implementation of a free cataract surgery program in rural China: a community-based randomized interventional study. Ophthalmology. 2013;120(2):260-265. doi: 10.1016/j.ophtha.2012.07.087.

Selected Research Grant Awards 選定的研究資助獎

Principal Investigator 首席研究員

  1. 2024: Health and Medical Research Fund, the Health Bureau, The Government of Hong Kong Special Administrative Region. Mitigating the long-term effects of COVID-19 on childhood myopia: An evidence-based, multidisciplinary strategy (Grant No.: 11220196). 3 years. 

  2. 2023: Health and Medical Research Fund, the Health Bureau, Hong Kong. Ocular imaging biomarkers for attention deficit hyperactivity disorder (ADHD). (Grant No.: 10210246). 2023-09-01 to 2025-08-31. 3 years. 

  3. 2022: Health and Medical Research Fund, the Health Bureau, Hong Kong. Novel Optical Coherence Tomography Imaging Biomarkers for High Myopia in Children and Adults to Assess Visual Damage Severity. (Grant No.: 09202466). 2022-11-01 to 2025-10-31. 3 years.

  4. 2020: Health and Medical Research Fund, the Health Bureau, Hong Kong. Novel Retinal Imaging Biomarkers for Children Amblyopia. (Grant No.: 07180826) 2020-09-01 to 2023-08-31. 3 years. 

  5. 2020: Start-up Grant, the Chinese University of Hong Kong. Ocular imaging. 2020-10-01 to 2025-09-31. 5 years. 

  6. 2023: Direct Grant for Research Medicine Panel, CUHK. 2022/2021. The Impact Novel Intelligent Glasses for Childhood Myopia Control and Healthy Lifestyle Promotion. (Grant No.: 4054770). From 2023-6-30 to 2024-06-29. 1 year. 

  7. 2021: Direct Grant for Research Medicine Panel, CUHK. 2020/2021. The role of diet in myopia progression and ocular traits in Chinese primary children in Hong Kong. (Grant No.: 4054634). From 2021-6-30 to 2023-06-29. 1 year. 

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Co-Investigator 共同研究員

  1. 2024: Health and Medical Research Fund, the Health Bureau, Hong Kong. Deep multimodal learning based management of myopia in children. (Grant No.: 11220206). 2024-11-18 to 2026-10-17. 3 years. 

  2. 2023: Research Grants Council, Faculties for Impact Cases – Funding. Prevention of myopia to protect our children’s vision. To 2025-09-30. 

  3. 2022: Research Grants Council, General Research Fund, Hong Kong. Low-Concentration Atropine for Myopia Progression (LAMP) Phase 5 Study: 7-year follow-up to evaluate the treatment cessation strategy: Stop versus Taper (GRF2022/2023, Grant No.: 14102422) 2023-01-01 to 2025-12-31. 

  4. 2021: National Natural Science Foundation of China (NSFC) 2021. 阿托品控制兒童近視的基因組學研究. (NSFC2021, Number: H1306). 

  5. 2020: Innovative Technology Fund (ITF), Hong Kong. Title: Low-concentration Atropine for Myopia Prevention (LAMP-2) Study. Project: PRP/042/19FX.2020-10-16 to 2023-10-16 

  6. 2021: Direct Grant for Research Medicine Panel, CUHK. Effect of Ocular Microbiome in Children receiving Low-concentration Atropine for Myopia Progression on Treatment Efficacy. (Grant No.: 178662514). 2021-06-30 to 2022-06-29. 

  7. 2021: Direct Grant for Research Medicine Panel, CUHK. Evaluating the disagreement of vertical cup-disc ratio measurement between fundus photograph and OCT measurement in children’s eyes and its effect on unnecessary ophthalmological referrals (Grant No.: 178644275). 2021-06-30 to 2022-06-29. 

  8. 2019: Direct Grant for Research Medicine Panel, CUHK. Myopia-related fundus changes and Visual Prognosis in Hong Kong Children and Adults with High Myopia: Hong Kong High Myopia Cohort. (Grant No.: 136482534). 2019-06-30 to 2022-06-29. 

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