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Professor Joseph Y.K. Chan 陳佑祺教授

Assistant Professor 助理教授

 

B.Eng.(MedE) Medical Engineering Programme (First Hon.), The University of Hong Kong, Ph.D., The University of Hong Kong

Phone 電話

(852) 2831 5361

Email 電郵

jchanyk@hku.hk

The HKU Scholars Hub 香港大學學術庫

HKU Scholars Hub

ORCID

0000-0002-1044-2668

About Professor Chan 關於陳教授

Professor Joseph Chan has a biomedical engineering background and dedicates himself to applying bioengineering technologies in the field of ophthalmology. His research interest lies in the design and testing of ophthalmic biomaterials, surgical tools and diagnostic tools, and the development of eye-on-a-chip microfluidic platforms for physiologically relevant studies in eye research. 

陳佑祺教授是一位生物醫學工程師，透過與醫生和工程師的緊密合作，專注運用多水相乳液系統、微流控技術及生物材料的知識來解決眼科醫學臨床問題。他的專長在於眼科生物材料的設計和測試，以及芯片眼微流控平台的開發。他在外科應用的眼用生物材料和術中工具的設計和測試以及各種體外眼模型的開發方面擁有豐富的經驗。

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The current research focuses include:

  • Eye-on-a-chip models for glaucoma-related and corneal scarring-related studies;

  • Microfluidic-based diagnostic tools for small volume sample analysis;

  • Assistive technologies that tackle the daily-living problems of visually impaired persons; and

  • Teaching innovations for medical and biomedical engineering undergraduate studies. 

目前的研究重點包括：

  • 利用微流控芯片眼平台研究眼科臨床相關問題；

  • 基於微流控技術用於小體積樣品分析的的診斷工具；

  • 解決視障人士日常生活問題的輔助技術；及

  • 醫學和生物醫學工程本科教學創新。

Grant Records 基金資助

(Principal Investigator 首席研究員)

  1. 2023 General Research Fund, Title: Revisiting the origin of and developing novel strategies to tackle silicone oil emulsification in vitreoretinal surgery

  2. 2023 HKU Small Equipment Grant, Title: An innovative microfluidic platform that enables precise and rapid fabrication of micro/nano-structures for drug delivery and micro-surgical applications

  3. 2023 Innovation and Technology Fund for Better Living (FBL), Title: Implementation of Augmented Reality (AR) technologies to educate the public the visual symptoms and progression of important vision-threatening diseases

  4. 2021 HKU Teaching Development Grant, Title: Novel collaborative framework between research departments and student academic organization, the “faculty-student association collaboration” model, for Flexible, sustainable and perpetual undergraduate research opportunities

  5. 2021 HKU Knowledge Exchange Impact Project Scheme, Title: Educating the elderly the visual symptoms of vision-threatening diseases through multisensory learning approach

  6. 2021 HKU Teaching Development Grant, Title: New capstone experience in undergraduate-initiated biomedical research with interdisciplinary collaboration and student-patient interactions 

  7. 2021 Seed Fund for Basic Research of the University of Hong Kong , Title: Fabrication of scaffoldless biological tissue templates using aqueous-three-phase-system

  8. 2020 HKU Teaching Development Grant, Title: Introduction of Augmented Reality (AR) technologies to educate medical students the visual symptoms and progression of important vision-threatening diseases

  9. 2020 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: A ‘Living’ Biological Bandage for Management of Ocular Surface Injuries

  10. 2019 Start-up Fund from LKS Faculty of Medicine of the University of Hong Kong, Title: A microsurgical instrument installed with nano-structured oil-absorbent material for effective silicone oil removal in vitreoretinal surgery

  11. 2019 Seed Fund for Basic Research for New Staff of the University of Hong Kong, Title: An “Artificial Eye” for studying pharmacokinetics of ophthalmic drugs and implants with drugs

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(Co-Investigator 聯合研究員)

  1. 2022 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: Automated fabrication of collagen-alginate composite ECT device for sustained drug delivery using microfluidics technology

  2. 2022 Innovation and Technology Fund (ITF) General Support Programme (GSP), Title: Biomedical Innovation and Outreach Programme (B.I.O. Programme)

  3. 2021 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: A surgical injector that rapidly and efficiently mix viscous fluids with precise small volume

Publications 出版物

​(*Corresponding Authors 通訊作者)

  1. Zhou L, Deng Y, Ren Y, Poon SHL, Chu WY, Wang H*, Chan YK*. Antibiotics-free nanomaterials against bacterial keratitis: eliminating infections with Reactive oxygen species (ROS). Chemical Engineering Journal 2024;482:148978 

  2. Xu F, Sun W, Ma W, Wang W, Kong D, Chan YK, Ma Q. All-aqueous microfluidic printing of multifunctional bioactive microfibers promote whole-stage wound healing. Colloids and Surfaces B-Biointerfaces. 2023;21;234:113720.

  3. Li B, Yang W, Shu R, Yang H, Yang F, Dai W, Chen W, Chan YK, Bai D, Deng Y. Antibacterial and Angiogenic (2A) Bio-Heterojunctions Facilitate Infectious Ischemic Wound Regeneration via an Endogenous–Exogenous Bistimulatory Strategy. Advanced Materials 2023;2307613.

  4. Huang Y, He S, Yu S, Johnson HM, Chan YK, Jiao Z, Wang S, Wu Z, Deng Y. MXene-Decorated Nanofibrous Membrane with Programmed Antibacterial and Anti-Inflammatory Effects via Steering NF-κB Pathway for Infectious Cutaneous Regeneration. Small 2023;2304119. 

  5. Dai W, Shu R, Yang F, Li B, Johnson HM, Yu S, Yang H, Chan YK, Yang W, Bai D, Deng Y. Engineered bio-heterojunction confers extra- and intracellular bacterial ferroptosis and hunger-triggered cell protection for diabetic wound repair. Advanced Materials 2023;2305277.

  6. Wang Q, Zang C, Chan YK, Wang S, Yang W, Deng Y, Zhu T, He M. CoFe2O4/MXene nanosheets modified hydrogel on PEEK with phototherapeutic and GPx-Mimetic activities for anti-pathogens in infectious bone defect repairment. Materials Chemistry and Physics 2023;128269. 

  7. Cheong N, Chui SW, Poon SHL, Wong HL, Shih KC*, Chan YK*. Emerging treatments for corneal endothelium decompensation – A systematic review. Graefe's Archive for Clinical and Experimental Ophthalmology 2023 doi: 10.1007/s00417-023-06129-7. 

  8. Peng Z, Zhang Y, Choi CL, Zhang P, Wu T*, Chan YK*. Continuous Roller Nanoimprint: Next Generation Lithography. Nanoscale 2023;15:11403-11421.

  9. He M, Wang Z, Yang H, Wang Q, Xiang D, Pang X, Chan YK, Yang W, Yin G, Deng Y, Sun D. Multi-Functional Bio-HJzyme: Revolutionizing Diabetic Skin Regeneration with its Glucose-Unlocked Sterilization and Programmed Anti-Inflammatory Effects. Advanced Science 2023, 2300986.

  10. Shu R, Sun J, Li B, Gao, X, He M, Chan YK, Shi J, Bai D, Yang W, Deng Y. Self-Tandem Bio-Heterojunctions Empower Orthopedic Implants with Amplified Chemo-Photodynamic Anti-Pathogenic Therapy and Boosted Diabetic Osseointegration. Advanced Functional Materials 2023, 2214873.

  11. Li Q, Wong HL, Ip YL, Chu WY, Li MS, Saha C, Shih KC, Chan YK*. Current Microfluidic Platforms for Reverse Engineering of Cornea. Materials Today Bio 2023:20:100634

  12. Jiang D, Yan C, Ge L, Chun Y, Huang Y, Chan YK, Chen C, Chen W, Zhou M, Lin B. Metabolomic analysis of aqueous humor reveals potential metabolite biomarkers for differential detection of macular edema. Eye and Vision 2023:10:14

  13. Bu Y, Shih KC, Wong HL, Kwok SS, Lo ACY, Chan YK, Ng ALK, Chan T, Jhanj V and Tong L. The Association between Altered Intestinal Microbiome, Impaired Systemic and Ocular Surface Immunity and Impaired Wound Healing Response after Alkaline-Chemical Injury in Diabetic Mice. Frontiers of Immunology 2023:14 DOI: 10.3389/fimmu.2023.1063069

  14. Deng Y, Ouyang X, Sun J, Shi X, Li Y, Chan YK, Yang W, Peng S. Rapid Sterilisation and Diabetic Cutaneous Regeneration Using Cascade Bio-Heterojunctions Through Glucose Oxidase-Primed Therapy. Bioactive Materials 2022:25:748-765

  15. Wong HL, Bu Y, Chan YK*, Shih KC*. Lycium barbarum Polysaccharide Promotes Corneal Re-Epithelialization after Alkaline Injury. Experimental Eye Research 2022:221:109151

  16. He S, Duan C, Yu Y, Wang S, Chan YK, Shi X, Huang J, Wang S, Peng S, Deng Y. Fusion Peptide-Engineered Polyetheretherketone Implants with Photo-Assisted Anti-Pathogen and Enhanced Angiogenesis for In Vivo Osseointegrative Fixation. Chemical Engineering Journal 2022:446:137453

  17. Li MS, Wong HL, Ip V, Peng Z, Yiu RSW, Yuan H, Wong JKW, Chan YK*. Current and Future Perspectives on Microfluidic Tear Analytic Devices. ACS Sensors 2022:7:1300-1314.

  18. Deng Y, Shi J, Chan YK, Bai D, Shu R, Shi X, Li L, Li Y, Li L, Yang X, Yang W. Heterostructured Metal-Organic Frameworks/Polydopamine Coating Endows Polyetheretherketone Implants with Multimodal Osteogenicity and Photoswitchable Disinfection. Advanced Healthcare Materials 2022:2200641.

  19. Yuan H, Lin JH, Dong ZS, Chen WT, Chan YK, Chang HT, Chen CF. Detection of pathogens using graphene quantum dots and gold nanoclusters on paper-based analytical devices. Sensors and Actuators B: Chemical 2022:363:131824

  20. Hung LT, Poon SHL, Yan WH, Lace R, Zhou L, Wong JKW, Williams R, Shih KC, Shum HC* Chan YK*. Scaffold-Free Strategy Using a PEG−Dextran Aqueous Two-Phase- System for Corneal Tissue Repair. ACS Biomaterials Science and Engineering 2022:8:1987-1999

  21. Ma KI, Saha C, Poon SHL, Yiu RSW, Shih KC, Chan YK*. Virtual reality and augmented reality— emerging screening and diagnostic techniques in ophthalmology: A systematic review. Survey of Ophthalmology 2022 DOI: 10.1016/j.survophthal.2022.02.001

  22. Peng L, Yang X, Ma D, Chan YK, Chen Y, Yang Z, Shi J, Mao Y, Li L, Yang W, Deng Y.  Bimetal Metal-Organic Framework Domino Micro-Reactor for Synergistic Antibacterial Starvation/Chemodynamic Therapy and Robust Wound Healing. Nanoscale 2022:14:2052-2064.

  23. Yang Y, Zhou X, Chan YK, Wang Z, Li L, Li J, Liang K, Deng Y. Photo-Activated Nanofibrous Membrane with Self-Rechargeable Antibacterial Function for Stubborn Infected Cutaneous Regeneration. Small 2022:2105988.

  24. Chen Y, Ip YL, Zhou L, Li PY, Chan YM, Lam WC, Li KKW, Steel DH, Chan YK*. What Is the Cause of Toxicity of Silicone Oil? Materials 2022:15:269.

  25. Fu L, Chan YK, Fang J, Liu J, Wen S, Shen L Wang J, Yu G, Nie L. Optical Coherence Tomography Angiography of the Macular Microcirculation in Acute Primary Angle Closure Treated with Phacoemulsification. International Ophthalmology 2022. https://doi.org/10.1007/s10792-021-02175-4.

  26. Poon SHL, Cheung J, Shih KC*, Chan YK. A systematic review of multimodal clinical biomarkers in the management of thyroid eye disease. Reviews in Endocrine & Metabolic Disorders 2022. https://doi.org/10.1007/s11154-021-09702-9.

  27. Zhou X, Wang Z, Chan YK, Yang Y, Jiao Z, Li L, Li J, Liang K, Deng Y. Infection Micromilieu-Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration. Advanced Functional Materials 2021:2109469.

  28. Liu K, Chan YK, Peng Xi, Liao M, Tang X, Xu Y, Yuan R, Liang J, Cai Y, Wang H. Improved dry eye symptoms and signs on patients with meibomian gland dysfunction by a dietary supplement. Frontiers in Medicine 2021, DOI:10.3389/fmed.2021.769132.

  29. Bu Y, Chan YK, Wong HL, Poon SHL, Lo ACY, Tong L, Shih KC. Gut Microbiome, Ocular Disease and The Immune System: A Systematic Review. Journal of Clinical Medicine 2021:10(20):4694.

  30. Wong HL, Kwok SS, Hung LT, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC*, Chan YK*. The Anti-Scarring Role of Lycium Barbarum Polysaccharide on Cornea Epithelial-Stromal Injury. Experimental Eye Research 2021;211:108747.

  31. Nie L, Xu J, Fu L, Ye Y, Chan YK, Li T, Pan W, Lu P. Changes in circumpapillary retinal vessel density after acute primary angle closure episode via OCT angiography. International Ophthalmology 2021 https://doi.org/10.1007/s10792-021-01793-2.

  32. Chan YK*, Laybourne J, Ng CO, Saha C, Yap HPY, Steel DH, Sandinha MT, Wong D*. An in-vitro study of subretinal perfluorocarbon liquid (PFCL) droplets and the physics of their retention and evacuation. Acta Ophthalmologica 2021;99:e1517-e1523.

  33. Kwok SS, Wong FSY, Shih KC, Chan YK, Bu Y, Chan TCY, Ng ALK, Lo ACY, Tong L, Yam GHF, Jhanji V. Lycium Barbarum Polysaccharide suppresses expression of fibrotic proteins in Primary human corneal fibroblasts. Journal of Clinical Medicine 2020;9(11):3572

  34. Chan YK*, Chen Y, Zhou L, Steel DH. Comment on “Fluid viscosity but not surface tension, determines the tamponade effect of intravitreal fluids in a novel in vitro eye model of retinal detachment” by A. Friehmann et al. (J. Mech. Behav. Biomed. Mater. 101 (2020) 103452). Journal of the Mechanical Behavior of Biomedical Materials 2020;113:104128

  35. Sandinha MT, Chan YK, Steel DH, Wong D. Spontaneous resolution of submacular perfluorocarbon liquids; Absorption or Evacuation? Retinal Cases & Brief Reports 2020 doi: 10.1097/ICB.0000000000001070.

  36. Poon SHL, Wong HL, Lo ACY, Jhanji V, Yuan H, Chen CF, Chan YK, Shih KC. A systematic review on advances in diagnostics for herpes simplex keratitis. Survey of Ophthalmology 2020;S0039-6257(20)30138-7.

  37. Chen Y, Kearns V, Zhou L, ZHOU, Sandinha T, Lam WC, Steel DH*, Chan YK*. Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long-term tamponade agents Acta Ophthalmologica, 2020;99:240-250.

  38. Peng Z, Zhou L, Wong JKW, Chan YK*. Eye-on-a-chip (EOC) models and their role in the future of ophthalmic drug discovery. Expert Review of Ophthalmology 2020;15:259-261.

  39. Nie L, Fu L, Chan YK, Fang A, Pan W. Combined Phacoemulsification with Goniosynechialysis under Ophthalmic Endoscope for Primary Angle Closure Glaucoma after Failed Trabeculectomy. Journal of Glaucoma 2020;29:941-947.

  40. Wong HL, Vishal J, Lo ACY, Poon SHL, Bu Y, Chan YK, Shih KC. A Systematic Review on Cornea Epithelial-Stromal Homeostasis. Ophthalmic Research 2020;64:178–191.

  41. Poon SHL, Wong HL, Bu Y, Lo ACY, Vishal J, Chan YK, Shih KC. A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface. Eye and Contact Lens: Science & Clinical Practice 2020;46(6):329-340.

  42. Fu L, Chan YK, Li J, Nie L, Li N, Pan W. Long Term Outcomes of Cataract Surgery in Severe and End Stage Glaucoma with Controlled IOP: A Retrospective Study. BMC Ophthalmology 2020;20;160.

  43. Chen Y, Zhou L, Chan YK*. Comment on “Safety of silicone oils as intraocular medical device: An in vitro cytotoxicity study” by M. R. Romano et al. (Exp. Eye Res. Vol 194, May 2020, 108018), Experimental Eye Research 2020;108032.

  44. Lu Y, Chan YK*, Lau LH, Wong D, Wong JKW, Shih K, Lai JSM, Shum HC*. Amphiphilic additives in silicone oil tamponade and emulsification: An eye-on-a-chip study, ACTA Ophthalmologica 2020;98:e232-e237.

  45. Fang A, Nie L, Wang P, Zheng J, Chan YK, Zhang Q, Liang Y, Jia Q. Silicone Tube Miniature Drainage Device Implanted under Scleral Flap for the Surgical Treatment of Glaucoma. Current Eye Research 2020; DOI: 10.1080/02713683.2019.1701687

  46. Qian Z, Chan YK, Wei L, Zheng B, Nie L, Pan W. Evaluation of two different anterior vitrectomies for fluid misdirection syndrome secondary to cataract surgery combined with goniosynechialysis. Journal of Ophthalmology 2020; 1934086.

  47. Bu Y, Shih KC, Kwok SS, Chan YK, Lo ACY, Chan TCY, Jhanji V, Tong L. Experimental Modelling of Cornea Wound Healing in Diabetes: Clinical Applications and Beyond. BMJ Open Diabetes Research & Care 2019;7:e000779.

  48. Lyu H, He Z, Chan YK, He X, Yu Y, Deng Y. Hierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity. Industrial & Engineering Chemistry Research 2019;58:19377-19385.

  49. Fu L, Kwok SS, Chan YK, Lai JSM, Pan W, Nie L, Shih KC. Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications. BioMed Research International 2019;2019:8397521.

  50. Nan L, Lai MYA, Tang MYH, Chan YK, Poon LLM, Shum HC. On-Demand Droplet Collection for Capturing Single Cells. Small 2019;1902889.

  51. Chan YK, Yan WH, Hung LT, Chao Y, Wu J, Shum HC. All-Aqueous Thin-Film-Flow-Induced Cell-Based Monolayers. ACS Applied Materials & Interfaces 2019;11:22869-22877. (Featured in Supplementary Cover).

  52. Wu J, Mak HK, Chan YK, Chen L, Kong C, Leung KS, Shum HC. An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures.Scientific Reports 2019;9:9057.

  53. Lu Y, Chan YK*, Lau LH, Chao Y, Shih K, Lai JSM, Wong D, Shum HC*. Adhesion of silicone oil and emulsification: An in vitro assessment using a microfluidic device and “Eye-on-a-Chip”, ACTA Ophthalmologica 2019;97:313-318

  54. Fu L, Chan YK, Nie L, Dai Q, Qian Z, Shih K, Lai SMJ, Huang R, Pan W. Ciliochoroidal Detachment after Ahmed Glaucoma Valve Implantation: A Retrospective Study. BMC Ophthalmology 2019;19:46.

  55. Nie L, Pan W, Fang A, Li Z, Qian Z, Fu L, Chan YK. Combined Phacoemulsification and Goniosynechialysis under Endoscope for Chronic Primary Angle-closure Glaucoma. Journal of Ophthalmology 2018;2018:7.

  56. Lin F, Lo ACY, Chan YK, So KW, Wong IYH, Shih KC, Lai SM. Transcorneal Electrical Stimulation Inhibits Microglial Activation and Enhances Retinal Ganglion Cell Survival after Acute Ocular Hypertensive Injury. Translational Vision Science & Technology 2018;7:7.

  57. Nie L, Fang A, Pan W, Ye H, Chan YK, Fu L, Qu J. Prospective Study on Ex-PRESS Implantation Combined with Phacoemulsification in Primary Angle-closure Glaucoma Coexisting Cataract: 3-year Results. Current Eye Research2018;43:1045-1051.

  58. Stefansson E, Chan YK, Bek T, Hardarson SH, Wong D, Wilson DI. Laws of physics help explain capillary non-perfusion in diabetic retinopathy. Eye2018;32:210-212.

  59. Wong D, Chan YK, Bek T, Wilson DI, Stefansson E. Intraocular currents, Bernoulli's principle and non-drainage scleral buckling for rhegmatogenous retinal detachment. Eye2018;32:213-221.

  60. Chan YK, Cheng HC, Wu J, Tang YHM, Chan ST, Wong D, Shum HC. A perfluorobutylpentane (F4H5)-based solution for the removal of residual emulsified silicone oil. Acta Ophthalmologica2018, 96:e38-e45.

  61. Chan YK, Lu Y, Czanner G, et al. In vitro experiment to elucidate the mechanism of the ‘soft shell technique’ for preventing subretinal migration of perfluoro-octane. British Journal of Ophthalmology 2017;101:389-394.

  62. Yuan H, Ma Q, Song Y, Tang MYH, Chan YK, Shum HC. Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems. Macromolecular Chemistry and Physics 2017;218:1600422.

  63. Chan YK, Czanner G, Shum HC, Williams RL, Cheung N, Wong D. Towards better characterisation and quantification of emulsification of silicone oil in vitro. Acta Ophthalmologica 2017;95:e385-e392.

  64. Song Y, Chan YK, Ma Q, Liu Z, Shum HC. All-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules. ACS Applied Materials & Interfaces. 2015;7:13925-13933.

  65. Chan YK, Sy KHS, Wong CY, Man PKE, Wong D, Shum HC. In vitro Modeling of Emulsification of Silicone Oil as Intraocular Tamponade Using Microengineered Eye-on-a-Chip. Investigative Ophthalmology & Visual Science 2015;56:3314-3319.

  66. Caramoy A, Kearns VR, Chan YK, et al. Development of emulsification resistant heavier-than-water tamponades using high molecular weight silicone oil polymers. Journal of Biomaterials Applications. 2015;30:212-220.

  67. Chan YK, Wong D, Yeung HK, Man PK, Shum HC. A Low-molecular-weight-oil Cleaner For Removal Of Leftover Silicone Oil Intraocular Tamponade. Investigative Ophthalmology & Visual Science 2015;56:1014-1022.

  68. Chan YK, Cheung N, Chan WSC, Wong D. Quantifying silicone oil emulsification in patients: are we only seeing the tip of the iceberg? Graefe's Arch Clin Exp Ophthalmol 2015;253:1671-1675.

  69. Chan YK, Williams RL, Wong D. Flow Behavior of Heavy Silicone Oil During Eye Movements. Investigative Ophthalmology & Visual Science 2014;55:8453-8457.

  70. Chan YK, Cheung N, Wong D. Factors Influencing the Shear Rate Acting on Silicone Oil to Cause Silicone Oil Emulsification. Investigative Ophthalmology & Visual Science 2014;55:7451-7456.

  71. Chan YK, Ng CO, Knox PC, Garvey MJ, Williams RL, Wong D. Emulsification of Silicone Oil and Eye Movements. Investigative Ophthalmology & Visual Science 2011;52:9721-9727.

Research Laboratories 研究實驗室

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Ocular Bioengineering Lab
眼科生物工程實驗室

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