Ocular Bioengineering Lab
眼科生物工程實驗室

Recent Publications 近期出版物

* Corresponding Author 通訊作者

1. Peng Z, Zhang Y, Choi CL, Zhang P, Wu T*, Chan YK*. Continuous Roller Nanoimprint: Next Generation Lithography. Nanoscale 2023 (Accepted)

2. Li Q, Wong HL, Ip YL, Chu WY, Li MS, Saha C, Shih KC, Chan YK*. Current Microfluidic Platforms for Reverse Engineering of Cornea. Materials Today Bio 2023:20:100634

3. Wong HL, Bu Y, Chan YK*, Shih KC*. Lycium barbarum Polysaccharide Promotes Corneal Re-Epithelialization after Alkaline Injury. Experimental Eye Research 2022:221:109151

4. Li MS, Wong HL, Ip V, Peng Z, Yiu RSW, Yuan H, Wong JKW, Chan YK*. Current and future perspectives on microfluidic devices for tear analysis. ACS Sensors 2022:7:1300-1314.

5. Hung LT, Poon SHL, Yan WH, Lace R, Zhou L, Wong JKW, Williams R, Shih KC, Shum HC* Chan YK*. Scaffold-Free Strategy Using a PEG−Dextran Aqueous Two-Phase-System for Corneal Tissue Repair. ACS Biomaterials Science and Engineering 2022:8:1987-1999

6. Ma KI, Saha C, Poon SHL, Yiu RSW, Shih KC, Chan YK*. Virtual reality and augmented reality— emerging screening and diagnostic techniques in ophthalmology: A systematic review. Survey of Ophthalmology 2022 DOI: 10.1016/j.survophthal.2022.02.001

7. Chen Y, Ip YL, Zhou L, Li PY, Chan YM, Lam WC, Li KKW, Steel DH, Chan YK*. What Is the Cause of Toxicity of Silicone Oil? Materials 2022:15:269.

8. Poon SHL, Cheung J, Shih KC*, Chan YK. A systematic review of multimodal clinical biomarkers in the management of thyroid eye disease. Reviews in Endocrine & Metabolic Disorders 2022. https://doi.org/10.1007/s11154-021-09702-9.

9. Wong HL, Kwok SS, Hung LT, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC*, Chan YK*. The Anti-Scarring Role of Lycium Barbarum Polysaccharide on Cornea Epithelial-Stromal Injury. Experimental Eye Research 2021;211:108747.

10. Chan YK*, Laybourne J, Ng CO, Saha C, Yap HPY, Steel DH, Sandinha MT, Wong D*. An in-vitro study of subretinal perfluorocarbon liquid (PFCL) droplets and the physics of their retention and evacuation. Acta Ophthalmologica 2021;99:e1517-e1523.

11. Chan YK*, Chen Y, Zhou L, Steel DH. Comment on “Fluid viscosity but not surface tension, determines the tamponade effect of intravitreal fluids in a novel in vitro eye model of retinal detachment” by A. Friehmann et al. (J. Mech. Behav. Biomed. Mater. 101 (2020) 103452). Journal of the Mechanical Behavior of Biomedical Materials 2020;113:104128.

12. Poon SHL, Wong HL, Lo ACY, Jhanji V, Yuan H, Chen CF, Chan YK, Shih KC. A systematic review on advances in diagnostics for herpes simplex keratitis. Survey of Ophthalmology 2020;S0039-6257(20)30138-7.

13. Chen Y, Kearns V, Zhou L, ZHOU, Sandinha T, Lam WC, Steel DH*, Chan YK*. Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long-term tamponade agents. Acta Ophthalmologica, 2020;99:240-250.

14. Peng Z, Zhou L, Wong JKW, Chan YK*. Eye-on-a-chip (EOC) models and their role in the future of ophthalmic drug discovery. Expert Review of Ophthalmology 2020;15:259-261.

15. Wong HL, Vishal J, Lo ACY, Poon SHL, Bu Y, Chan YK, Shih KC. A Systematic Review on Cornea Epithelial-Stromal Homeostasis. Ophthalmic Research 2020;64:178–191.

16. Poon SHL, Wong HL, Bu Y, Lo ACY, Vishal J, Chan YK, Shih KC. A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface. Eye and Contact Lens: Science & Clinical Practice 2020;46(6):329-340.

17. Chen Y, Zhou L, Chan YK*. Comment on “Safety of silicone oils as intraocular medical device: An in vitro cytotoxicity study” by M. R. Romano et al. (Exp. Eye Res. Vol 194, May 2020, 108018), Experimental Eye Research 2020;108032.

18. Lu Y, Chan YK*, Lau LH, Wong D, Wong JKW, Shih K, Lai JSM, Shum HC*. Amphiphilic additives in silicone oil tamponade and emulsification: An eye-on-a-chip study, ACTA Ophthalmologica 2020;98:e232-e237.

19. Chan YK, Yan WH, Hung LT, Chao Y, Wu J, Shum HC. All-Aqueous Thin-Film-Flow-Induced Cell-Based Monolayers. ACS Applied Materials & Interfaces 2019;11:22869-22877. (Featured in Supplementary Cover).

20. Lu Y, Chan YK*, Lau LH, Chao Y, Shih K, Lai JSM, Wong D, Shum HC*. Adhesion of silicone oil and emulsification: An in vitro assessment using a microfluidic device and “Eye-on-a-Chip”, ACTA Ophthalmologica 2019;97:313-318.

21. Wong HL, Kwok SS, Hung LT, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC*, Chan YK*. The Anti-Scarring Role of Lycium Barbarum Polysaccharide on Cornea Epithelial-Stromal Injury. Experimental Eye Research 2021 2021;211:108747.

22. Lu Y, Chan YK*, Lau LH, Wong D, Wong JKW, Shih K, Lai JSM, Shum HC*. Amphiphilic additives in silicone oil tamponade and emulsification: An eye-on-a-chip study, ACTA Ophthalmologica 2020;98:e232-e237.

23. Chan YK, Yan WH, Hung LT, Chao Y, Wu J, Shum HC. All Aqueous Thin-film-flow-induced Cell-based Monolayer. ACS Applied Materials & Interfaces 2019;11:22869-22877. (Featured in Supplementary Cover).

24. Lu Y, Chan YK*, Lau LH, Chao Y, Shih K, Lai JSM, Wong D, Shum HC*. Adhesion of silicone oil and emulsification: An in vitro assessment using a microfluidic device and “Eye-on-a-Chip”, ACTA Ophthalmologica 2019;97:313-318.

25. Chan YK, Lu Y, Czanner G, Wu J, Cheng HC, Hussain R, Sakamoto T, Shum HC, Wong D. In vitro experiment to elucidate the mechanism of the ‘soft shell technique’ for preventing subretinal migration of perfluoro-octane. British Journal of Ophthalmology 2017;101:389-394.

26. Chan YK, Sy KHS, Wong CY, Man PKE, Wong D, Shum HC. In vitro Modeling of Emulsification of Silicone Oil as Intraocular Tamponade Using Microengineered Eye-on-a-Chip. Investigative Ophthalmology & Visual Science 2015;56:3314-3319.

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Grant Records 基金資助

(Principal Investigator 首席研究員)

1. 2023 General Research Fund, Title: Revisiting the origin of and developing novel strategies to tackle silicone oil emulsification in vitreoretinal surgery

2. 2023 HKU Small Equipment Grant, Title: An innovative microfluidic platform that enables precise and rapid fabrication of micro/nano-structures for drug delivery and micro-surgical applications

3. 2023 Innovation and Technology Fund for Better Living (FBL), Title: Implementation of Augmented Reality (AR) technologies to educate the public the visual symptoms and progression of important vision-threatening diseases

4. 2021 HKU Teaching Development Grant , Title: Novel collaborative framework between research departments and student academic organization, the “faculty-student association collaboration” model, for Flexible, sustainable and perpetual undergraduate research opportunities

5. 2021 HKU Knowledge Exchange Impact Project Scheme, Title: Educating the elderly the visual symptoms of vision-threatening diseases through multisensory learning approach

6. 2021 HKU Teaching Development Grant, Title: New capstone experience in undergraduate-initiated biomedical research with interdisciplinary collaboration and student-patient interactions 

7. 2021 Seed Fund for Basic Research of the University of Hong Kong , Title: Fabrication of scaffoldless biological tissue templates using aqueous-three-phase-system

8. 2020 HKU Teaching Development Grant, Title: Introduction of Augmented Reality (AR) technologies to educate medical students the visual symptoms and progression of important vision-threatening diseases

9. 2020 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: A ‘Living’ Biological Bandage for Management of Ocular Surface Injuries

10. 2019 Start-up Fund from LKS Faculty of Medicine of the University of Hong Kong, Title: A microsurgical instrument installed with nano-structured oil-absorbent material for effective silicone oil removal in vitreoretinal surgery

11. 2019 Seed Fund for Basic Research for New Staff of the University of Hong Kong, Title: An “Artificial Eye” for studying pharmacokinetics of ophthalmic drugs and implants with drugs

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(Co-Investigator 聯合研究員)

1. 2022 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: Automated fabrication of collagen-alginate composite ECT device for sustained drug delivery using microfluidics technology

2. 2022 Innovation and Technology Fund (ITF) General Support Programme (GSP), Title: Biomedical Innovation and Outreach Programme (B.I.O. Programme)

3. 2021 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: A surgical injector that rapidly and efficiently mix viscous fluids with precise small volume

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Patents and Patent Applications 專利和專利申請

1. “OCULAR ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEROF” by Yau Kei Chan, Liangyu Zhou. US Provisional patent application filed with the University of Hong Kong, Patent Application No. 63/499,590 filed on 2 May 2023

2. “SELECTIVE OIL-ABSORBING CELLULOSE-BASED AEROGEL MICROPARTICLES AND MICROFIBERS” by Yau Kei CHAN, Ying CHEN. US Provisional patent application filed with the University of Hong Kong, Patent Application No. 63/496,021 filed on 14 Apr 2023

3. “A Semifluorinated Alkane Based Cleaner for Removing Emulsified Droplets in the Eye to Reduce the Complications Associated the Emulsification of Silicone Oil” by Ho Cheung Shum, Sai Hung David Wong, Yau Kei Chan. US Provisional Patent application filed with the University of Hong Kong, Application No. 62/084,953, 26 Nov 2014

4. “OPHTHALMOLOGICAL RINSING AGENT AND METHOD OF USE THEREFORE” by Ho Cheung Shum, Sai Hung David Wong, Yau Kei Chan. US Patent application filed with the University of Hong Kong, US 2014/0335172 A1, 29 Apr 2014

5. “眼科清洗剂及其方法”， 发明人: 岑浩璋， 黄世雄，陈佑祺。中国国家知识产权局发明专利，专利号ZL 2014 80026555.1，2018年05月02日 (获授权)

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