Goals of Research Group 研究組目標

• To understand corneal and ocular surface disease from a basic science and translational research point of view, with a focus on the following 從基礎科學和轉化研究的角度了解角膜和眼表疾病，重點關注以下方面：

  • Dry eye disease epidemiology and associations with systemic disease 乾眼病流行病學及其與全身性疾病的關聯

  • Novel therapies in dry eye disease and corneal neuropathic pain 乾眼病和角膜神經性疼痛的新療法

  • The interaction between ocular surface immunity, gut microflora and corneal epithelial wound healing in health and disease 眼表免疫、腸道菌群和角膜上皮傷口癒合在健康和疾病中的相互作用

  • The molecular basis for corneal remodelling and prevention of stromal fibrosis after injury 角膜重塑與預防損傷後間質纖維化的分子基礎

Selected Group Publications  (4 per research area, in descending order of impact factor)

選定的團體出版物（每個研究領域各4篇，按 Impact factor 降序排列）

​Ocular Surface Inflammation 眼表炎症

• Hui P.Y., Cheung M.C., Perera R.A.P.M., Ng K.C., Bui H.T., Ho C.W.J., Ng M.M.T., Kuok I.T., Shih K.C., Tsao G.S.W., Poon L.M.L., Peiris J.S.M., Nicholls J.M. and Chan M.C.W., Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures, The Lancet Respiratory Medicine. 2020.

• Poon SH, Wong WH, Lo AC, Yuan H, Chen CF, Jhanji V, Chan YK, Shih KC. A Systematic Review on Advances in Diagnostics for Herpes Simplex Keratitis. Surv Ophthalmol. 2020

• Shih K.C., Lun C.N., Jhanji V., Thong B.Y. and Tong L., Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome, Journal of Inflammation. United Kingdom, 2017

• Chow, L.L.W., Shih, K.C., Chan, J.C.Y. et al. Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study. BMC Ophthalmol. 2017

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Cornea Wound Healing 角膜傷口癒合

• Kwok SS, Wong F -Y, Shih KC, Chan Y-K, Bu Y, Chan T -Y, Ng A -K, Lo A -Y, Tong L, Yam G -F, Jhanji V. Lycium barbarum Polysaccharide Suppresses Expression of Fibrotic Proteins in Primary Human Corneal Fibroblasts. Journal of Clinical Medicine. 2020

• Bu Y., Shih K.C., Kwok S.S., Chan Y.K., Lo A.C.Y., Chan T.C.Y., Jhanji V. and Tong L., Experimental modelling of cornea wound healing in diabetes: clinical applications and beyond, BMJ Open Diabetes Research & Care. 2019​

• Wong H.L., Bu Y., Chan Y.K. and Shih K.C., Lycium barbarum polysaccharide promotes corneal Re-epithelialization after alkaline injury, Experimental Eye Research. 2022, 109151. 

• ​Wong HL, Hung LT, Kwok SS, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC, Chan YK, The anti-scarring role of Lycium barbarum polysaccharide on cornea epithelial-stromal injury, Experimental Eye Research. 2021

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Dry Eye Syndrome 乾眼症

• Shih K.C., Lam K.S.L. and Tong L., A systematic review on the impact of diabetes mellitus on the ocular surface, Nutrition & Diabetes. 2017

• Chan T.C.Y., Wan K.H., Shih K.C. and Jhanji V., Advances in dry eye imaging: the present and beyond, British Journal of Ophthalmology. 2017

• Ma A., Mak M.S., Shih K.C., Tsui C.K., Cheung R.K., Lee S.H., Leung H., Leung J.N., Leung J.T., Van-Boswell M.Z., Wong M.T., Ng L.K.A., Lee C.H.P., Jhanji V. and Tong L., Association of long-term glycaemic control on tear break up times and dry eye symptoms in Chinese patients with type 2 diabetes, Clinical & Experimental Ophthalmology. 2018.

• Chuang J., Shih K.C., Chan T.C.Y., Wan K.H., Jhanji V. and Tong L., Preoperative optimization of ocular surface disease before cataract surgery, Journal of Cataract and Refractive Surgery. Elsevier, 2018, 43 (11), 1596 –1607.

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Funding 資金

(Principal Investigator 首席研究員)

1. 2020 Li Shu Pui Medical Foundation Fellowship 2020 李樹培醫學基金：

Development and validation of an AI-assisted clinical decision making system for laser refractive surgery 

HKD 585,630

2. 2020 Timothy KC Liu Memorial Fund Award, Hong Kong Ophthalmological Society:

A randomized controlled trial on the therapeutic efficacy of Intense Pulsed Light in treating Prostaglandin Analogue related Dry Eye Disease

HKD $9634

3. 2019 Health and Medical Research Fund 醫療衛生研究基金：

Evaluation of the accuracy of diagnostic and management decision by teleophthalmology in comparison with face-to face consultation

HKD 613,848

4. 2019 SK Yee Medical Foundation Grant 2019 余兆麒醫療基金：

Intense pulsed light therapy in the management of moderate to severe ocular surface disease

HKD 400,000

5. 2018 Timothy KC Liu Memorial Fund Award, Hong Kong Ophthalmological Society:

Lycium Barbarum Polysaccharide Solution as a Novel Therapuetic Agent in the Prevention of Cornea Scarring

HKD 30,000

6. 2017 SK Yee Medical Foundation Grant 2017 余兆麒醫療基金：

The introduction of Descemet’s membrane endothelial keratoplasty surgery for public patients and skill transfer to cornea surgeons in Hong Kong

HKD 278,600

7. 2015 SK Yee Medical Foundation Grant 2015 余兆麒醫療基金：

To Introduce Boston Keratoprosthesis for the Treatment of Corneal Blindness in Queen Mary Hospital

HKD 249,460