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Dr. Joseph CHAN Yau Kei, 陳佑祺

Assistant Professor

Tel no. : (852) 2831 5361
Fax no. : (852) 2817 0491
Email : jchanyk@hku.hk

Qualifications
  • B.Eng.(MedE) Medical Engineering Programme (First Hon.) University of Hong Kong
  • Ph.D. (Ophthalmology) University of Hong Kong

 

Research Interests
Dr. Chan is an ocular bioengineer and his expertise lies on the design and testing of ophthalmic biomaterials, and development of eye-on-a-chip microfluidic platforms. Hs is also experienced in in-vitro culture of both primary cells and cell lines of eye-related cells and design of drug delivery systems for ophthalmic applications. He has a strong background particularly in the design, development and testing of silicone oils and other intraoperative ophthalmic tools. Currently he is exploring the use of all-aqueous immiscible liquid-liquid system as platforms to tissue engineer transplantable eye-related structures for clinical applications. He is also exploring research opportunities in treatments of glaucoma and had co-authored in publications about topics of transcorneal electrical stimulations, Ex-PRESS shunt and goniosynechialysis.

The current research focus includes:

  • All-aqueous immiscible liquid-liquid system as platforms to form cellular structures for potential transplantation purposes in the eye
    (Topics: Self-assembly of monolayer cell aggregates, planar cell constructs, celloidosomes, and biomaterials templates like hydrogels and Janus particles)
  • Eye-on-a-chip microfluidic platforms
    (Topics: Eye-cavity-on-a-chip to screen silicone oil based on emulsification, Cornea-on-a-chip and Anterior-chamber-on-a-chip)
  • Intravitreal drug delivery
    (Topics: the role of collagen on the drug transport in vitreous, engineer systems for encapsulation of Avastin)
  • Endotamponade agents including perfluorocarbon liquids and silicone oil
    (Topics: Mechanisms of emulsification of silicone oil, the use of hyaluronate to prevent subretinal PFCL migration)
  • Development of ocular intraoperative tools
    (Topics: Medical devices that aim to (1) reduce complications induced by silicone oil or (2) facilitate retinal detachment)

Publications
  1. Nan L, Lai MYA, Tang MYH, Chan YK, Poon LLM, Shum HC. On-Demand Droplet Collection for Capturing Single Cells. Small 2019;1902889.
  2. Lu Y, Chan YK*, Lau LH, Wong D, Wong JKW, Shih K, Lai JSM, Shum HC*. Amphiphilic additives in silicone oil tamponade and emulsification: an eye‐on‐a‐chip study. ACTA Ophthalmologica 2019 (Accepted).
  3. Chan YK, Yan WH, Hung LT, Chao Y, Wu J, Shum HC. All-Aqueous Thin-Film-Flow-Induced Cell-Based Monolayers. ACS Applied Materials & Interfaces 2019;11:22869-22877. (Featured in Supplementary Cover).
  4. Wu J, Mak HK, Chan YK, Chen L, Kong C, Leung KS, Shum HC. An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures.Scientific Reports 2019;9:9057.
  5. Lu Y, Chan YK*, Lau LH, Chao Y, Shih K, Lai JSM, Wong D, Shum HC*. Adhesion of silicone oil and emulsification: An in vitro assessment using a microfluidic device and “Eye-on-a-Chip”, ACTA Ophthalmologica 2019;97:313-318
  6. Fu L, Chan YK, Nie L, Dai Q, Qian Z, Shih K, Lai SMJ, Huang R, Pan W. Ciliochoroidal Detachment after Ahmed Glaucoma Valve Implantation: A Retrospective Study. BMC Ophthalmology 2019;19:46.
  7. Nie L, Pan W, Fang A, Li Z, Qian Z, Fu L, Chan YK. Combined Phacoemulsification and Goniosynechialysis under Endoscope for Chronic Primary Angle-closure Glaucoma. Journal of Ophthalmology 2018;2018:7.
  8. Lin F, Lo ACY, Chan YK, So KW, Wong IYH, Shih KC, Lai SM. Transcorneal Electrical Stimulation Inhibits Microglial Activation and Enhances Retinal Ganglion Cell Survival after Acute Ocular Hypertensive Injury. Translational Vision Science & Technology 2018;7:7.
  9. Stefansson E, Chan YK, Bek T, Hardarson SH, Wong D, Wilson DI. Laws of physics help explain capillary non-perfusion in diabetic retinopathy. Eye2018;32:210-212.
  10. Chan YK, Cheng HC, Wu J, Tang YHM, Chan ST, Wong D, Shum HC. A perfluorobutylpentane (F4H5)-based solution for the removal of residual emulsified silicone oil. Acta Ophthalmologica2018, 96:e38-e45.
  11. Yuan H, Ma Q, Song Y, Tang MYH, Chan YK, Shum HC. Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems. Macromolecular Chemistry and Physics 2017;218:1600422.
  12. Chan YK, Czanner G, Shum HC, Williams RL, Cheung N, Wong D. Towards better characterisation and quantification of emulsification of silicone oil in vitro. Acta Ophthalmologica 2017;95:e385-e392.
  13. Song Y, Chan YK, Ma Q, Liu Z, Shum HC. All-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules. ACS Applied Materials & Interfaces. 2015;7:13925-13933.
  14. Chan YK, Sy KHS, Wong CY, Man PKE, Wong D, Shum HC. In vitro Modeling of Emulsification of Silicone Oil as Intraocular Tamponade Using Microengineered Eye-on-a-Chip. Investigative Ophthalmology & Visual Science 2015;56:3314-3319.
  15. Caramoy A, Kearns VR, Chan YK, et al. Development of emulsification resistant heavier-than-water tamponades using high molecular weight silicone oil polymers. Journal of Biomaterials Applications. 2015;30:212-220.
  16. Chan YK, Wong D, Yeung HK, Man PK, Shum HC. A Low-molecular-weight-oil Cleaner For Removal Of Leftover Silicone Oil Intraocular Tamponade. Investigative Ophthalmology & Visual Science 2015;56:1014-1022.
  17. Chan YK, Cheung N, Chan WSC, Wong D. Quantifying silicone oil emulsification in patients: are we only seeing the tip of the iceberg? Graefe's Arch Clin Exp Ophthalmol 2015;253:1671-1675.
  18. Chan YK, Williams RL, Wong D. Flow Behavior of Heavy Silicone Oil During Eye Movements. Investigative Ophthalmology & Visual Science 2014;55:8453-8457.
  19. Chan YK, Cheung N, Wong D. Factors Influencing the Shear Rate Acting on Silicone Oil to Cause Silicone Oil Emulsification. Investigative Ophthalmology & Visual Science 2014;55:7451-7456.
  20. Chan YK, Ng CO, Knox PC, Garvey MJ, Williams RL, Wong D. Emulsification of Silicone Oil and Eye Movements. Investigative Ophthalmology & Visual Science 2011;52:9721-9727.

* Corresponding Author